August 5, 2020

Laser Therapy for Neuropathic Pain 2020

Two studies on the effects of laser therapy on patients suffering from Neuropathic Pain.


Study 1: Low level laser therapy for the patients with painful diabetic peripheral neuropathy – A systematic review

Anju M 1, Saleena Ummer V 2, Arun G Maiya 3, Manjunath Hande 4
Affiliations expand
PMID: 31405692 DOI: 10.1016/j.dsx.2019.07.035


Background: Low Level Laser Therapy (LLLT) is an emerging treatment modality for management of neuropathic pain. It works by triggering biochemical changes with in cells.

Objective: This systematic review focused on finding evidence on the effectiveness of LLLT on treatment of painful diabetic neuropathy.

Methods: We conducted a systematic review (PubMed, Web of Science, CINAHL and Cochrane) to find the evidence on effectiveness of LLLT on treatment of painful diabetic neuropathy. Randomized and non-randomized studies were included in the review.

Results: A total of 627 studies were screened. After the exclusion criteria (duplicate, animal studies, LLLT for treating other neuralgias) 6 studies were included in the study. The outcome measure that were considered were the difference in pain score and nerve conduction velocity test and quality of life questionnaire.

Conclusion: The evidence obtained shows LLLT has a positive effect in controlling diabetic neuropathic pain.

Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.




Study 2: Effect of Modified Laser Transcutaneous Irradiation on Pain and Quality of Life in Patients with Diabetic Neuropathy

Milena Valdinéia da Silva Leal 1, Mário Oliveira Lima 2, Renata Amadei Nicolau 1 3, Teresa Marly Teles de Carvallho 4, Jesus Antonio de Carvalho Abreu 5, Diego Rodrigues Pessoa 6, Emilia Angela Lo Schiavo Arisawa 1
Affiliations expand
PMID: 32195640 DOI: 10.1089/photob.2019.4714


Background: Diabetic neuropathy (DN) is one of the major complications developed by individuals with diabetes mellitus. DN is responsible for a high morbidity and mortality rate and impacts the public health and medical assistance resources. Intradermic laser irradiation on blood (ILIB) consists of the application of light beams on the radial arterial, providing anti-inflammatory and vasodilator effects, antiarrhythmic action, reduction of glucose, and stabilization of the hormonal and immunological systems. These effects help to maintain the physiological dynamics of the body.

Objective: The goal of this research was to evaluate the effects of ILIB to relieve pain and improve the quality of life in DN patients. The sample comprised 30 diabetic volunteers with DN, randomly distributed into 3 groups: Control-conventional treatment; ILIB-100 mW, 660 ± 10 nm, 30 applications in total, divided into 3 stages of 10 applications, 30 min each, daily, with a 20-day interval between each stage.

SILIB-same protocol described for ILIB, with the equipment switched off. Before and after the application of the therapeutic protocols, all volunteers were evaluated by the following instruments: Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), visual analog scale, Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), and PAIN DETECT scale. Collected data were statistically analyzed with a 95% confidence interval, p < 0.05.

Results: The ILIB group presented significantly lower pain levels and a better quality of life compared with the control and SILIB groups.

Conclusions: This study demonstrated that ILIB therapy was effective in reducing pain and improving quality of life in patients with DN.




Painful peripheral neuropathy is a common neurological disorder characterized by numbness, weakness, tingling and pain, often starting in the hands or feet. There are more than 100 different types of peripheral neuropathy, according to the U.S. National Institute of Neurological Disorders and Stroke (NINDS).

Is neuropathic pain the same as neuropathy? For many patients, the intensity of their symptoms can wax and wane throughout the day. Although neuropathic pain is thought to be associated with peripheral nerve problems, such as neuropathy caused by diabetes or spinal stenosis, injuries to the brain or spinal cord can also lead to chronic neuropathic pain.


Back to Blogs