AUTONOMIC NERVOUS SYSTEM BENEFITS

Irradiation of the Stellate Ganglion reduced VAS scores and increased local temp due to an increase regional blood flow by a reduction in vascular tone
Hashimoto et al., Laser Therapy 1997 (9) pp 7–12.

AUTONOMIC NERVOUS SYSTEM BENEFITS

LLLT improves ANS function
Lasers Surg Med. 2014 Dec;46(10):796–803.

BACTERIA AND VIRUSES

LLLT can inhibit some bacteria and viruses.
Lett Appl Microbiol. 2016 Mar;62(3):230–6.
Lasers Med Sci. 2016 Apr;31(3):549–56.
Antiviral Res. 2014 Oct;110:70-6.

BONE REGENERATION

Laser improves osteoblastic formation, bone strength in fractures, implant stability, and can improve osteonecrosis of the jaw.
Lasers Med Sci. 2010 Jul;25(4):559–69).
J Orthop Surg Res. 2010 Jan 4;5(1):1.
J Photochem Photobiol B. 2016 Oct;163:14–21.

CARDIAC PATHOLOGY BENEFITS

LLLT improves cardiac function.
Photomed Laser Surg. 2016 Nov;34(11):516–524
Lasers Med Sci. 2016 Nov 17.

CARPAL TUNNEL SYNDROME

Meta-analysis demonstrated that low-level laser improved hand grip, pain, and sensory nerve function.
Medicine (Baltimore).2016 Aug;95(31): 4424.

CELL AND PHYSIOLOGICAL BENEFITS INCREASES:

Cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).

DECREASES:

Prostaglandin E2, substance P, cyclooxygenase 2
(Cox 2), muscle tension.
J Clin Las Med Surg 2004; 22 (2)141–150.

CELLULAR BENEFITS

INCREASES: Mitochondria and ATP production, Cytochrome oxidase and singlet oxygen, tissue regeneration genes and motor proteins, RNA DNA synthesis, growth factors, cell metabolism, angiogenesis, and mitosis. Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.

CORTISONE HAS SIMILAR EFFECTS AS LIGHT

Animal study; 810-nm laser was almost as good as cortisone at reducing swelling.
Higher doses showed most benefit.
Laser therapy reduced joint swelling and correlated with decreased serum prostaglandins.
Castano AP, Lasers Surg Med 2007 Jul;39(6):543–50.

CORTISONE IMPROVED WITH LLLT

Laser plus cortisone more effective than cortisone by itself.
Photomed Laser Surg. 2010 Oct;28(5):639–46.

DEPTH OF PENETRATION

LLLT passing through the skull with an 808 nm wavelength laser penetrated approximately 40 mm (1.6 inches)
Lasers Surg Med. 2015 Apr;47(4):312–22.

808 nm laser produced 1 mW/cm2 was achieved at 3.4 cm (1.36 inches), but for 980 nm achieved only 2.2 cm (less than 1 inch). It was determined that 808 nm of light penetrates as much as 54% deeper than 980 nm light. Photomed Laser Surg. 2013 Apr;31(4):163–8.

FROZEN SHOULDER BENEFITS

A significant improvement in laser therapy compared to the control group. The treatment group experienced significantly less pain and significantly improved disability scores. Range of motion in the treatment group was better than placebo.
Photomed Laser Surg. 2008 Mar 16.

HAIR LOSS

Meta-analysis of studies covered in this review found an overall
improvement in hair regrowth, thickness, and patient satisfaction following LLLT.
Lasers Surg Med. 2016 Apr 25.

HIGHER DOSES INHIBIT

Lower Doses Stimulate, Higher Doses Inhibit. Using 14X the dose inhibited tissue repair.
J Biophotonics. 2016 Mar 15.

HIGHER DOSES INHIBIT

Lower Doses Stimulate, Higher Doses Inhibit
Cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.
Photomed Laser Surg. 2006 Dec;24(6):705–14.
INCREASE MOUTH OPENING, DECREASED MUSCULAR PAIN, DECREASED EATING DIFFICULTY, AND DECREASED TENDER POINTS
Photomed Laser Surg. 2006; 25 (5): 637–80.

INFLAMMATORY MEDIATOR INHIBITION

DECREASES: Inflammatory mediators, Cytokine receptors, Inflammatory proteins, Genes that code for inflammation, Proapoptotic proteins.
Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.

INTENSITY OF THE LASER RADIATION WAS REDUCED BY 66% AFTER BEING TRANSMITTED THROUGH THE SKIN.

Most laser radiation was absorbed within the first 1mm of skin.
Acupunct Eletrother Res., 2007;321 (1–2);81-6.

LLLT BRAIN DISORDERS

Harvard research shows that LLLT is a promising treatment for many types of brain disorders.
BBA Clin. 2016 Oct 1;6:113–124.

LOWER POWER DENSITIES SHOWED BEST COLLAGEN STRUCTURE

The best organization of collagen were shown by the lower densities. All wavelengths and fluences used in this study were efficient at accelerating the healing process, with lower densities better than higher, hotter densities.
Photomed Laser Surg. 2006 Dec;24(6):754–8.

LLLT VS LOW-INTENSITY PULSED ULTRASOUND (LIPUS)

LIPUS enhanced bone repair by promoting bone resorption; LLLT accelerated this process through bone formation.
Photomed Laser Surg. 2006 Dec;24(6):735–40.

MEDICATION STRONGER WITH LIGHT

Laser Helps TB Treatment: Laser plus medication better than medication alone for tuberculosis.
Indian J Tuberc. 2010 Apr;57(2):80–6.

MITOCHONDRAL FUNCTION IMPROVED

Improves oxygen production, promoting cellular survival, Increased Cytochrome c oxidase—terminal enzyme of the electron transport chain and a strong photoacceptor and other mitochondral enzymes.
J Photochem Photobiol B. 2006 Nov 17.

MUSCLE PERFORMANCE AND LASER

Meta-analysis of 533 studies showed can increase in muscle mass after training, and a decrease in inflammation and oxidative stress in muscle biopsies.
J Biophotonics. 2016 Nov 22.

NECK PAIN BENEFITS

LLLT improves chronic neck pain and function.
Open Orthop J. 2013 Sep 20;7:396–419.

NERVE GROWTH STIMULATION

Controlled trial showed regeneration of sciatic nerve and myelination in rats.
Rochkind. Photomed & Laser Surg. 2007, 25(3): 137–143.

NERVE HEALING

LLLT accelerates peripheral nerve regeneration.
Lasers Med Sci. 2015 Dec;30(9):2319–24.

NON-STEROIDALS: COMPARATIVE EFFECT

LLLT reduces inflammation and improves function, in some cases superior to NSAIDs.
Lasers Med Sci. 2016 Winter;7(1):45–50.

ORAL MUCOSITIS LLLT

LLLT reduces pain in chemotherapy induced oral mucositis.
J Lasers Med Sci. 2016 Winter;7(1):45–50.

NON-STEROIDALS: COMPARATIVE EFFECT

LLLT reduces inflammation and improves function, in some cases superior to NSAIDs.
Lasers Med Sci. 2016 Winter;7(1):45–50.

PARKINSON’S IMPROVED WITH LIGHT

LLL improves nerve function with Parkinson’s.
Molecular Degen 2009 Jun 17;4:26

PENETRATION UP TO 23 CM

Lasers and LED’s of Optimal Wavelength Penetrate up to 23 cm (4 studies).
Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.

PERIPHERAL NEUROPATHY

LLLT helps patients with diabetic peripheral neuropathy.
Acta Med Iran. 2013 Sep 9;51(8):543–7.

PHYSIOLOGICAL BENEFITS

INCREASES: cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).
DECREASES: Prostaglandin E2, substance P, cyclooxygenase 2 (Cox 2), muscle tension.
J Clin Las Med Surg 2004; 22 (2)141–150.

PSYCHIATRIC DISORDERS IMPROVED

LLL applied to skull decreased depression and anxiety.
Behavioral and Brain Functions, 2009, 5:46, 8 December 2009.

6% OF PHOTONS REACH SPINAL CORD

Applied directly to SP of porcine subjects; 6% of photons reached cord and increased CGRP/mRNA.
Kimberly Byrnes, PhD, NAALT, 2003/2004.

STROKE

Animal Study; Neurological deficits improved.
Lasers Surg Med. 2006 Jan;38(1):70–3.
Stroke. 2006 Oct;37(10):2620–4.

STROKE HELPED WITH LIGHT

Laser applied to skull improves brain following stroke.
Curr Cardiol Rep. 2010 Jan;12(1):29–33

TEMPORMANDIBULAR JOINT (TMJ)

Decrease of pain and anti-inflammatory effects; confirmed by thermographic examination.
Photomed Laser Surg. 2006 Aug;24(4):522–7.

TENDINITIS AND MYOFASCIAL PAIN BENEFITS

Acute tendinitis had the best response.
Logdberg-Anersson et al., Laser Therapy 1997 (9) pp 79–86.

TENDINITIS BENEFITS

LLLT proven to help tendinitis.
Acta Ortop Bras. 2015 Jan-Feb;23(1):47–9.

THYROID FUNCTION IMPROVES

Laser improves the function of the thyroid based on lab values with chronic autoimmune thyroiditis.
Lasers Surg Med. 2010 Aug;42(6):589–96.