IMPORTANT NOTE:
THE STUDIES SHOWN IN THIS WEBSITE ARE FOR INFORMATIONAL PURPOSES ONLY AND ARE NOT MEDICAL ADVICE.
RESEARCH DATA
DEMENTIA
J Alzheimers Dis.; 2021;83(4):1431-1452.Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies, Farzad Salehpour, All of the included studies reported positive results.
WOUND REPAIR
Wound Repair Regen, 2022 Mar;30(2):245-257.Photobiomodulation promotes hair regeneration in injured skin. Yuehou Zhang, The application of photobiomodulation (PBM) in regenerative medicine has expanded to the treatment of alopecia caused by various reasons. We now have proof that we understand how PBM helps to stimulate hair growth.
WAVELENGTH
Lasers Surg Med. 2021 Nov;53(9):1279-1293. Photobiomodulation Response From 660 nm is Different and More Durable, Christine Fuchs, These findings demonstrate that 660 nm is a different physiological pathway than 980 nm and provides a more durable and effective healing response than from 980 nm.
AUTONOMIC NERVOUS SYSTEM BENEFITS
Irradiation of the Stellate Ganglion reduced VAS scores and increased local temp due to an increase regional blood flow by a reduction in vascular tone
Hashimoto et al., Laser Therapy 1997 (9) pp 7–12.
CARDIAC PATHOLOGY BENEFITS
LLLT improves cardiac function.
Photomed Laser Surg. 2016 Nov;34(11):516–524
Lasers Med Sci. 2016 Nov 17.
BACTERIA AND VIRUSES
LLLT can inhibit some bacteria and viruses.
Lett Appl Microbiol. 2016 Mar;62(3):230–6.
Lasers Med Sci. 2016 Apr;31(3):549–56.
Antiviral Res. 2014 Oct;110:70-6.
BONE REGENERATION
Laser improves osteoblastic formation, bone strength in fractures, implant stability, and can improve osteonecrosis of the jaw.
Lasers Med Sci. 2010 Jul;25(4):559–69).
J Orthop Surg Res. 2010 Jan 4;5(1):1.
J Photochem Photobiol B. 2016 Oct;163:14–21.
CELLULAR BENEFITS
INCREASES: Mitochondria and ATP production, Cytochrome oxidase and singlet oxygen, tissue regeneration genes and motor proteins, RNA DNA synthesis, growth factors, cell metabolism, angiogenesis, and mitosis. Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.
CARPAL TUNNEL SYNDROME
Meta-analysis demonstrated that low-level laser improved hand grip, pain, and sensory nerve function.
Medicine (Baltimore).2016 Aug;95(31): 4424.
CELL AND PHYSIOLOGICAL BENEFITS INCREASES
Cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).
DECREASES:
Prostaglandin E2, substance P, cyclooxygenase 2
(Cox 2), muscle tension.
J Clin Las Med Surg 2004; 22 (2)141–150.
DEPTH OF PENETRATION
LLLT passing through the skull with an 808 nm wavelength laser penetrated approximately 40 mm (1.6 inches)
Lasers Surg Med. 2015 Apr;47(4):312–22.
808 nm laser produced 1 mW/cm2 was achieved at 3.4 cm (1.36 inches), but for 980 nm achieved only 2.2 cm (less than 1 inch). It was determined that 808 nm of light penetrates as much as 54% deeper than 980 nm light. Photomed Laser Surg. 2013 Apr;31(4):163–8.
CORTISONE HAS SIMILAR EFFECTS AS LIGHT
Animal study; 810-nm laser was almost as good as cortisone at reducing swelling.
Higher doses showed most benefit.
Laser therapy reduced joint swelling and correlated with decreased serum prostaglandins.
Castano AP, Lasers Surg Med 2007 Jul;39(6):543–50.
CORTISONE IMPROVED WITH LLLT
Laser plus cortisone more effective than cortisone by itself.
Photomed Laser Surg. 2010 Oct;28(5):639–46.
HIGHER DOSES INHIBIT
Lower Doses Stimulate, Higher Doses Inhibit. Using 14X the dose inhibited tissue repair.
J Biophotonics. 2016 Mar 15.
FROZEN SHOULDER BENEFITS
A significant improvement in laser therapy compared to the control group. The treatment group experienced significantly less pain and significantly improved disability scores. Range of motion in the treatment group was better than placebo.
Photomed Laser Surg. 2008 Mar 16.
HAIR LOSS
Meta-analysis of studies covered in this review found an overall
improvement in hair regrowth, thickness, and patient satisfaction following LLLT.
Lasers Surg Med. 2016 Apr 25.
INTENSITY OF THE LASER RADIATION WAS REDUCED BY 66% AFTER BEING TRANSMITTED THROUGH THE SKIN.
Most laser radiation was absorbed within the first 1mm of skin.
Acupunct Eletrother Res., 2007;321 (1–2);81-6.
HIGHER DOSES INHIBIT
Lower Doses Stimulate, Higher Doses Inhibit
Cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.
Photomed Laser Surg. 2006 Dec;24(6):705–14.
INCREASE MOUTH OPENING, DECREASED MUSCULAR PAIN, DECREASED EATING DIFFICULTY, AND DECREASED TENDER POINTS
Photomed Laser Surg. 2006; 25 (5): 637–80.
INFLAMMATORY MEDIATOR INHIBITION
DECREASES: Inflammatory mediators, Cytokine receptors, Inflammatory proteins, Genes that code for inflammation, Proapoptotic proteins.
Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.
LLLT VS LOW-INTENSITY PULSED ULTRASOUND (LIPUS)
LIPUS enhanced bone repair by promoting bone resorption; LLLT accelerated this process through bone formation.
Photomed Laser Surg. 2006 Dec;24(6):735–40.
LLLT BRAIN DISORDERS
Harvard research shows that LLLT is a promising treatment for many types of brain disorders.
BBA Clin. 2016 Oct 1;6:113–124.
LOWER POWER DENSITIES SHOWED BEST COLLAGEN STRUCTURE
The best organization of collagen were shown by the lower densities. All wavelengths and fluences used in this study were efficient at accelerating the healing process, with lower densities better than higher, hotter densities.
Photomed Laser Surg. 2006 Dec;24(6):754–8.
MUSCLE PERFORMANCE AND LASER
Meta-analysis of 533 studies showed can increase in muscle mass after training, and a decrease in inflammation and oxidative stress in muscle biopsies.
J Biophotonics. 2016 Nov 22.
MEDICATION STRONGER WITH LIGHT
Laser Helps TB Treatment: Laser plus medication better than medication alone for tuberculosis.
Indian J Tuberc. 2010 Apr;57(2):80–6.
MITOCHONDRAL FUNCTION IMPROVED
Improves oxygen production, promoting cellular survival, Increased Cytochrome c oxidase—terminal enzyme of the electron transport chain and a strong photoacceptor and other mitochondral enzymes.
J Photochem Photobiol B. 2006 Nov 17.
NERVE HEALING
LLLT accelerates peripheral nerve regeneration.
Lasers Med Sci. 2015 Dec;30(9):2319–24.
NECK PAIN BENEFITS
LLLT improves chronic neck pain and function.
Open Orthop J. 2013 Sep 20;7:396–419.
NERVE GROWTH STIMULATION
Controlled trial showed regeneration of sciatic nerve and myelination in rats.
Rochkind. Photomed & Laser Surg. 2007, 25(3): 137–143.
NON-STEROIDALS: COMPARATIVE EFFECT
LLLT reduces inflammation and improves function, in some cases superior to NSAIDs.
Lasers Med Sci. 2016 Winter;7(1):45–50.
NON-STEROIDALS: COMPARATIVE EFFECT
LLLT reduces inflammation and improves function, in some cases superior to NSAIDs.
Lasers Med Sci. 2016 Winter;7(1):45–50.
ORAL MUCOSITIS LLLT
LLLT reduces pain in chemotherapy induced oral mucositis.
J Lasers Med Sci. 2016 Winter;7(1):45–50.
PERIPHERAL NEUROPATHY
LLLT helps patients with diabetic peripheral neuropathy.
Acta Med Iran. 2013 Sep 9;51(8):543–7.
PARKINSON’S IMPROVED WITH LIGHT
LLL improves nerve function with Parkinson’s.
Molecular Degen 2009 Jun 17;4:26
PENETRATION UP TO 23 CM
Lasers and LED’s of Optimal Wavelength Penetrate up to 23 cm (4 studies).
Desmet K, et al. Photomed Laser Surg. 2006 Jun;24(2):121–128.
6% OF PHOTONS REACH SPINAL CORD
Applied directly to SP of porcine subjects; 6% of photons reached cord and increased CGRP/mRNA.
Kimberly Byrnes, PhD, NAALT, 2003/2004.
PHYSIOLOGICAL BENEFITS
INCREASES: cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).
DECREASES: Prostaglandin E2, substance P, cyclooxygenase 2 (Cox 2), muscle tension.
J Clin Las Med Surg 2004; 22 (2)141–150.
PSYCHIATRIC DISORDERS IMPROVED
LLL applied to skull decreased depression and anxiety.
Behavioral and Brain Functions, 2009, 5:46, 8 December 2009.
TEMPORMANDIBULAR JOINT (TMJ)
Decrease of pain and anti-inflammatory effects; confirmed by thermographic examination.
Photomed Laser Surg. 2006 Aug;24(4):522–7.
STROKE
Animal Study; Neurological deficits improved.
Lasers Surg Med. 2006 Jan;38(1):70–3.
Stroke. 2006 Oct;37(10):2620–4.
STROKE HELPED WITH LIGHT
Laser applied to skull improves brain following stroke.
Curr Cardiol Rep. 2010 Jan;12(1):29–33
THYROID FUNCTION IMPROVES
Laser improves the function of the thyroid based on lab values with chronic autoimmune thyroiditis.
Lasers Surg Med. 2010 Aug;42(6):589–96.
TENDINITIS AND MYOFASCIAL PAIN BENEFITS
Acute tendinitis had the best response.
Logdberg-Anersson et al., Laser Therapy 1997 (9) pp 79–86.